Open AccessEffects of heart failure on brain-type Na+ channels in rabbit ventricular myocytes
Author(s) -
Arie O. Verkerk,
Antoni C.G. van Ginneken,
Toon A.B. van Veen,
Hanno L. Tan
Publication year - 2007
Publication title -
ep europace
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.119
H-Index - 102
eISSN - 1532-2092
pISSN - 1099-5129
DOI - 10.1093/europace/eum121
Subject(s) - medicine , tetrodotoxin , myocyte , pressure overload , gating , contraction (grammar) , biophysics , patch clamp , heart failure , coupling (piping) , electrophysiology , cardiology , biology , materials science , metallurgy , cardiac hypertrophy
Brain-type alpha-subunit isoforms of the Na(+) channel are present in various cardiac tissue types and may control pacemaker activity and excitation-contraction coupling. Heart failure (HF) alters pacemaker activity and excitation-contraction coupling. Here, we studied whether HF alters brain-type Na(+) channel properties.
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