A method for the simultaneous analysis of mRNA levels of multiple cardiac ion channels with a multi-probe RNase protection assay | Zendy

Yuki Iwasaki | Zendy; Takeshi Yamashita | Zendy; Akiko Sekiguchi | Zendy; Seiji Hatano | Zendy; Kouichi Sagara | Zendy; Hiroyuki Iinuma | Zendy; Long-tai Fu | Zendy; Yoshinori Kobayashi | Zendy; Takao Katoh | Zendy; Teruo Takano | Zendy

Open Access

A method for the simultaneous analysis of mRNA levels of multiple cardiac ion channels with a multi-probe RNase protection assay

Author(s) -

Yuki Iwasaki,

Takeshi Yamashita,

Akiko Sekiguchi,

Seiji Hatano,

Kouichi Sagara,

Hiroyuki Iinuma,

Long-tai Fu,

Yoshinori Kobayashi,

Takao Katoh,

Teruo Takano

Publication year - 2006

Publication title -

ep europace

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.119

H-Index - 102

eISSN - 1532-2092

pISSN - 1099-5129

DOI - 10.1093/europace/eul099

Subject(s) - ion channel , complementary dna , electrophysiology , messenger rna , template , microbiology and biotechnology , biophysics , biology , medicine , gene , biochemistry , nanotechnology , materials science , receptor

Various pathological conditions can alter cardiac electrophysiological properties not only by physiological responses but also by modifying the gene expression of ion channels (electrical remodelling). To investigate the underlying mechanisms of the latter, electrophysiological alterations would require a simultaneous and comprehensive analysis of the mRNA level of the ion channel genes.

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