Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation | Zendy

Ingrid E. Christophersen | Zendy; Morten S. Olesen | Zendy; Bo Liang | Zendy; Martin N. Andersen | Zendy; Anders Peter Larsen | Zendy; Jonas B. Nielsen | Zendy; Stig Haunsø | Zendy; SørenPeter Olesen | Zendy; Arnljot Tveit | Zendy; Jesper Hastrup Svendsen | Zendy; Nicole Schmitt | Zendy

Open Access

Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation

Author(s) -

Ingrid E. Christophersen,

Morten S. Olesen,

Bo Liang,

Martin N. Andersen,

Anders Peter Larsen,

Jonas B. Nielsen,

Stig Haunsø,

SørenPeter Olesen,

Arnljot Tveit,

Jesper Hastrup Svendsen,

Nicole Schmitt

Publication year - 2012

Publication title -

european heart journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.336

H-Index - 293

eISSN - 1522-9645

pISSN - 0195-668X

DOI - 10.1093/eurheartj/ehs442

Subject(s) - medicine , potassium channel , mutant , mutation , loss function , atrial fibrillation , cancer research , genetics , gene , biology , phenotype

Genetic factors may be important in the development of atrial fibrillation (AF) in the young. KCNA5 encodes the potassium channel α-subunit KV1.5, which underlies the voltage-gated atrial-specific potassium current IKur. KCNAB2 encodes KVβ2, a β-subunit of KV1.5, which increases IKur. Three studies have identified loss-of-function mutations in KCNA5 in patients with idiopathic AF. We hypothesized that early-onset lone AF is associated with high prevalence of genetic variants in KCNA5 and KCNAB2.

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