Coronary microembolization during early reperfusion: infarct extension, but protection by ischaemic postconditioning | Zendy

Andreas Skyschally | Zendy; Barbara Walter | Zendy; Gerd Heusch | Zendy

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Coronary microembolization during early reperfusion: infarct extension, but protection by ischaemic postconditioning

Author(s) -

Andreas Skyschally,

Barbara Walter,

Gerd Heusch

Publication year - 2012

Publication title -

european heart journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.336

H-Index - 293

eISSN - 1522-9645

pISSN - 0195-668X

DOI - 10.1093/eurheartj/ehs434

Subject(s) - medicine , cardiology , myocardial infarction , cardioprotection , ischemia , infarction , reperfusion injury , embolism , blood flow , reperfusion therapy

Reperfusion injury following acute myocardial infarction impacts not only on the myocardium but also on the coronary microcirculation, and microembolization from the culprit lesion contributes to microvascular obstruction. Prior experimental studies have not accounted for microembolization in ischaemia/reperfusion injury and not considered microembolization as a confounder and target of protection by ischaemic postconditioning. We therefore investigated the impact of microembolization during reperfusion on infarct size and cardioprotection by postconditioning.

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