A diabetes-predictive amino acid score and future cardiovascular disease | Zendy

Martin Magnusson | Zendy; Gregory D. Lewis | Zendy; Ulrika Ericson | Zendy; Marju OrhoMelander | Zendy; Bo Hedblad | Zendy; Gunnar Engström | Zendy; Gerd Östling | Zendy; Clary B. Clish | Zendy; Thomas J. Wang | Zendy; Robert E. Gerszten | Zendy; Olle Melander | Zendy

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A diabetes-predictive amino acid score and future cardiovascular disease

Author(s) -

Martin Magnusson,

Gregory D. Lewis,

Ulrika Ericson,

Marju OrhoMelander,

Bo Hedblad,

Gunnar Engström,

Gerd Östling,

Clary B. Clish,

Thomas J. Wang,

Robert E. Gerszten,

Olle Melander

Publication year - 2012

Publication title -

european heart journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.336

H-Index - 293

eISSN - 1522-9645

pISSN - 0195-668X

DOI - 10.1093/eurheartj/ehs424

Subject(s) - medicine , diabetes mellitus , disease , amino acid , phenylalanine , isoleucine , metabolic syndrome , endocrinology , leucine , biochemistry , chemistry

We recently identified a metabolic signature of three amino acids (tyrosine, phenylalanine, and isoleucine) that strongly predicts diabetes development. As novel modifiable targets for intervention are needed to meet the expected increase of cardiovascular disease (CVD) caused by the diabetes epidemic, we investigated whether this diabetes-predictive amino acid score (DM-AA score) predicts development of CVD and its functional consequences.

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