ABCA1 mutation carriers with low high-density lipoprotein cholesterol are characterized by a larger atherosclerotic burden | Zendy

A.E. Bochem | Zendy; Diederik F. van Wijk | Zendy; Adriaan G. Holleboom | Zendy; Raphaël Duivenvoorden | Zendy; M. Mahdi Motazacker | Zendy; Geesje M. DallingaThie | Zendy; E. de Groot | Zendy; John J.P. Kastelein | Zendy; Aart J. Nederveen | Zendy; G. Kees Hovingh | Zendy; E.S.G. Stroes | Zendy

Open Access

ABCA1 mutation carriers with low high-density lipoprotein cholesterol are characterized by a larger atherosclerotic burden

Author(s) -

A.E. Bochem,

Diederik F. van Wijk,

Adriaan G. Holleboom,

Raphaël Duivenvoorden,

M. Mahdi Motazacker,

Geesje M. DallingaThie,

E. de Groot,

John J.P. Kastelein,

Aart J. Nederveen,

G. Kees Hovingh,

E.S.G. Stroes

Publication year - 2012

Publication title -

european heart journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.336

H-Index - 293

eISSN - 1522-9645

pISSN - 0195-668X

DOI - 10.1093/eurheartj/ehs376

Subject(s) - medicine , abca1 , body mass index , cardiology , cholesterol , diabetes mellitus , endocrinology , high density lipoprotein , risk factor , transporter , gene , genetics , biology

Low HDL-C is a potent risk factor for cardiovascular disease (CVD). Yet, mutations in ABCA1, a major determinant of circulating HDL-C levels, were previously not associated with CVD risk in cohort studies. To study the consequences of low plasma levels of high-density lipoprotein cholesterol (HDL-C) due to ATP-binding cassette transporter A1 (ABCA1) dysfunction for atherosclerotic vascular disease in the carotid arteries.

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