Activation of intestinal peroxisome proliferator-activated receptor- increases high-density lipoprotein production | Zendy

S. Colin | Zendy; Olivier Briand | Zendy; Véronique Touche | Zendy; Kristiaan Wouters | Zendy; Morgane Baron | Zendy; François Pattou | Zendy; Rémy Hanf | Zendy; Anne Tailleux | Zendy; Giulia Chinetti | Zendy; Bart Staels | Zendy; Sophie Lestavel | Zendy

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Activation of intestinal peroxisome proliferator-activated receptor- increases high-density lipoprotein production

Author(s) -

S. Colin,

Olivier Briand,

Véronique Touche,

Kristiaan Wouters,

Morgane Baron,

François Pattou,

Rémy Hanf,

Anne Tailleux,

Giulia Chinetti,

Bart Staels,

Sophie Lestavel

Publication year - 2012

Publication title -

european heart journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.336

H-Index - 293

eISSN - 1522-9645

pISSN - 0195-668X

DOI - 10.1093/eurheartj/ehs227

Subject(s) - chylomicron , medicine , endocrinology , fenofibrate , peroxisome proliferator activated receptor , apolipoprotein b , receptor , peroxisome , liver x receptor , lipoprotein , lipid metabolism , peroxisome proliferator activated receptor alpha , ldl receptor , fibrate , cholesterol , nuclear receptor , biology , biochemistry , transcription factor , very low density lipoprotein , gene

Peroxisome proliferator-activated receptor (PPAR)-α is a transcription factor controlling lipid metabolism in liver, heart, muscle, and macrophages. Peroxisome proliferator-activated receptor-α activation increases plasma HDL cholesterol and exerts hypotriglyceridaemic actions via the liver. However, the intestine expresses PPAR-α, produces HDL and chylomicrons, and is exposed to diet-derived PPAR-α ligands. Therefore, we examined the effects of PPAR-α activation on intestinal lipid and lipoprotein metabolism.

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