Generation of patient-specific induced pluripotent stem cell-derived cardiomyocytes as a cellular model of arrhythmogenic right ventricular cardiomyopathy | Zendy

Dongrui Ma | Zendy; Heming Wei | Zendy; Jun Lü | Zendy; Shuswen Ho | Zendy; Guangqing Zhang | Zendy; Xiaoming Sun | Zendy; Yingzi Oh | Zendy; Suat Hoon Tan | Zendy; Mah Lee Ng | Zendy; Winston Shim | Zendy; Philip Wong | Zendy; Reginald Liew | Zendy

Open Access

Generation of patient-specific induced pluripotent stem cell-derived cardiomyocytes as a cellular model of arrhythmogenic right ventricular cardiomyopathy

Author(s) -

Dongrui Ma,

Heming Wei,

Jun Lü,

Shuswen Ho,

Guangqing Zhang,

Xiaoming Sun,

Yingzi Oh,

Suat Hoon Tan,

Mah Lee Ng,

Winston Shim,

Philip Wong,

Reginald Liew

Publication year - 2012

Publication title -

european heart journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.336

H-Index - 293

eISSN - 1522-9645

pISSN - 0195-668X

DOI - 10.1093/eurheartj/ehs226

Subject(s) - plakoglobin , induced pluripotent stem cell , desmoplakin , intercalated disc , medicine , connexin , microbiology and biotechnology , myocyte , cardiomyopathy , reprogramming , pathology , cell , gap junction , biology , signal transduction , heart failure , embryonic stem cell , gene , catenin , genetics , wnt signaling pathway , intracellular

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a primary heart muscle disorder associated with sudden cardiac death. Its pathophysiology is still poorly understood. We aimed to produce an in vitro cellular model of ARVC using patient-specific induced pluripotent stem cell (iPSC)-derived cardiomyocytes and determine whether the model could recapitulate key features of the disease phenotype.

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