The tryptophan metabolite 3-hydroxyanthranilic acid lowers plasma lipids and decreases atherosclerosis in hypercholesterolaemic mice | Zendy

Lei Zhang | Zendy; О. А. Овчинникова | Zendy; P. Andreas Jonsson | Zendy; Anna M. Lundberg | Zendy; M Berg | Zendy; Göran K. Hansson | Zendy; Daniel F.J. Ketelhuth | Zendy

Open Access

The tryptophan metabolite 3-hydroxyanthranilic acid lowers plasma lipids and decreases atherosclerosis in hypercholesterolaemic mice

Author(s) -

Lei Zhang,

О. А. Овчинникова,

P. Andreas Jonsson,

Anna M. Lundberg,

M Berg,

Göran K. Hansson,

Daniel F.J. Ketelhuth

Publication year - 2012

Publication title -

european heart journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.336

H-Index - 293

eISSN - 1522-9645

pISSN - 0195-668X

DOI - 10.1093/eurheartj/ehs175

Subject(s) - inflammation , medicine , metabolite , arteriosclerosis , endocrinology , cholesterol , receptor , foam cell , ldl receptor , lipid metabolism , triglyceride , pharmacology , lipoprotein

Cardiovascular disease is the most common cause of death in the world and atherosclerosis, an inflammatory process in the vessel wall, accounts for the majority of these deaths. The tryptophan metabolite 3-hydroxyanthranilic acid (3-HAA) has been shown to inhibit inflammation in different experimental autoimmune disease models. However, the effect of 3-HAA in atherosclerosis has never been explored.

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