Determinants of aortic sclerosis progression: implications regarding impairment of nitric oxide signalling and potential therapeutics | Zendy

Aaron L. Sverdlov | Zendy; D. Ngo | Zendy; Wai Ping Alicia Chan | Zendy; Yuliy Y. Chirkov | Zendy; Bernard J. Gersh | Zendy; John J. McNeil | Zendy; John D. Horowitz | Zendy

Open Access

Determinants of aortic sclerosis progression: implications regarding impairment of nitric oxide signalling and potential therapeutics

Author(s) -

Aaron L. Sverdlov,

D. Ngo,

Wai Ping Alicia Chan,

Yuliy Y. Chirkov,

Bernard J. Gersh,

John J. McNeil,

John D. Horowitz

Publication year - 2012

Publication title -

european heart journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.336

H-Index - 293

eISSN - 1522-9645

pISSN - 0195-668X

DOI - 10.1093/eurheartj/ehs171

Subject(s) - medicine , nitric oxide , aortic valve stenosis , aortic valve , stenosis , cardiology , multiple sclerosis , ramipril , immunology , blood pressure

Aortic valve stenosis (AS) and its precursor, aortic valve sclerosis (ASc), occur frequently in Western populations. Investigations to retard the progression of AS using statins have been unsuccessful. Development of ASc in humans is associated with increased aortic valve backscatter (AVBS) and poor tissue nitric oxide (NO) responsiveness. In an animal model, ramipril retarded AS/ASc development. We have now set out to identify factors associated with the progression of ASc in humans.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research