Paradoxical progression of atherosclerosis related to low-density lipoprotein reduction and exposure to ezetimibe | Zendy

G. N. Taylor | Zendy; Todd C. Villines | Zendy; Eric J. Stanek | Zendy

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Paradoxical progression of atherosclerosis related to low-density lipoprotein reduction and exposure to ezetimibe

Author(s) -

G. N. Taylor,

Todd C. Villines,

Eric J. Stanek

Publication year - 2012

Publication title -

european heart journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.336

H-Index - 293

eISSN - 1522-9645

pISSN - 0195-668X

DOI - 10.1093/eurheartj/ehs105

Subject(s) - ezetimibe , medicine , statin , cardiology , univariate analysis , coronary artery disease , cholesterol , intima media thickness , hyperlipidemia , endocrinology , carotid arteries , multivariate analysis , diabetes mellitus

Ezetimibe reduces low-density lipoprotein cholesterol (LDL-C) but has complex actions on cholesterol transport and metabolism, and thus, LDL-C reduction may not solely define its overall effects. We explored the relationship between treatment effects and cumulative exposure to ezetimibe, with its effects on carotid intima-media thickness (CIMT) in ARBITER 6-HALTS.

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