Effect of mitochondrial aldehyde dehydrogenase-2 genotype on cardioprotection in patients with congenital heart disease | Zendy

Hao Zhang | Zendy; Dingxu Gong | Zendy; Yujian Zhang | Zendy; Shoujun Li | Zendy; Shengshou Hu | Zendy

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Effect of mitochondrial aldehyde dehydrogenase-2 genotype on cardioprotection in patients with congenital heart disease

Author(s) -

Hao Zhang,

Dingxu Gong,

Yujian Zhang,

Shoujun Li,

Shengshou Hu

Publication year - 2012

Publication title -

european heart journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.336

H-Index - 293

eISSN - 1522-9645

pISSN - 0195-668X

DOI - 10.1093/eurheartj/ehs061

Subject(s) - aldh2 , medicine , cardioprotection , aldehyde dehydrogenase , heart disease , cardiology , tetralogy of fallot , surgery , myocardial infarction , biochemistry , biology , gene

About 40% of East Asians carry an aldehyde dehydrogenase-2*2 (ALDH2*2) allele, and the influence of the ALDH2*2 allele on human cardioprotection has not been studied. This study was designed to evaluate the effect of ALDH2*2 allele on cardioprotection of patients with congenital heart diseases after open-heart surgery.

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