Cardiomyocyte-expressed farnesoid-X-receptor is a novel apoptosis mediator and contributes to myocardial ischaemia/reperfusion injury | Zendy

Jun Pu | Zendy; Ancai Yuan | Zendy; Peiren Shan | Zendy; Erhe Gao | Zendy; Xiaoliang Wang | Zendy; Yajing Wang | Zendy; Wayne Bond Lau | Zendy; Walter J. Koch | Zendy; Xinliang Ma | Zendy; Ben He | Zendy

Open Access

Cardiomyocyte-expressed farnesoid-X-receptor is a novel apoptosis mediator and contributes to myocardial ischaemia/reperfusion injury

Author(s) -

Jun Pu,

Ancai Yuan,

Peiren Shan,

Erhe Gao,

Xiaoliang Wang,

Yajing Wang,

Wayne Bond Lau,

Walter J. Koch,

Xinliang Ma,

Ben He

Publication year - 2012

Publication title -

european heart journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.336

H-Index - 293

eISSN - 1522-9645

pISSN - 0195-668X

DOI - 10.1093/eurheartj/ehs011

Subject(s) - farnesoid x receptor , nuclear receptor , medicine , mediator , receptor , cardiac function curve , apoptosis , microbiology and biotechnology , function (biology) , reperfusion injury , ischemia , bioinformatics , biology , gene , heart failure , transcription factor , biochemistry

Emerging evidence indicates that nuclear receptors play a critical regulatory role in cardiovascular physiology/pathology. Recently, farnesoid-X-receptor (FXR), a member of the metabolic nuclear receptor superfamily, has been demonstrated to be expressed in vascular cells, with important roles in vascular physiology/pathology. However, the potential cardiac function of FXR remains unclear. We investigated the cardiac expression and biological function of FXR.

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