Open AccessCardioprotective effects of mineralocorticoid receptor antagonists at reperfusion
Author(s) -
Katharina Schmidt,
Renaud Tissier,
Bijan Ghaleh,
Tim Drogies,
Stephan B. Felix,
Thomas Krieg
Publication year - 2009
Publication title -
european heart journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.336
H-Index - 293
eISSN - 1522-9645
pISSN - 0195-668X
DOI - 10.1093/eurheartj/ehp555
Subject(s) - medicine , eplerenone , cardioprotection , mineralocorticoid receptor , ischemia , pharmacology , adenosine , reperfusion injury , endocrinology , aldosterone
Pre-treatment with mineralocorticoid receptor (MR) antagonists is reported to reduce myocardial infarct size from ischaemia/reperfusion. Here, we tested whether the MR antagonists potassium canrenoate and eplerenone could protect in the more clinically relevant schedule of administration at the end of ischaemia.