Open Accessα2C-Adrenoceptor polymorphism is associated with improved event-free survival in patients with dilated cardiomyopathy
Author(s) -
Vera RegitzZagrosek,
Berthold Hocher,
Martin Bettmann,
Marc Brede,
Kerstin Hadamek,
Carolin Gerstner,
H. Lehmkuhl,
Roland Hetzer,
Lutz Hein
Publication year - 2005
Publication title -
european heart journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.336
H-Index - 293
eISSN - 1522-9645
pISSN - 0195-668X
DOI - 10.1093/eurheartj/ehi659
Subject(s) - medicine , heart transplantation , cardiology , heart failure , cardiomyopathy , dilated cardiomyopathy , transplantation , proportional hazards model , heart disease
The sympathetic nervous system plays a central role in cardiac growth but its overstimulation is associated with increased mortality in patients with chronic heart failure. Pre-synaptic alpha2-adrenoceptors are essential feedback regulators to control the release of norepinephrine from sympathetic nerves. In this study we tested whether a deletion polymorphism in the human alpha2C-adrenoceptor gene (alpha2CDel322-325) affects progression of heart failure in patients with dilated cardiomyopathy (DCM).