Probing the evolutionary robustness of two repurposed drugs targeting iron uptake in Pseudomonas aeruginosa | Zendy

Chiara Rezzoagli | Zendy; David K. Wilson | Zendy; Michael Weigert | Zendy; Stefan Wyder | Zendy; Rolf Kümmerli | Zendy

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Probing the evolutionary robustness of two repurposed drugs targeting iron uptake in Pseudomonas aeruginosa

Author(s) -

Chiara Rezzoagli,

David K. Wilson,

Michael Weigert,

Stefan Wyder,

Rolf Kümmerli

Publication year - 2018

Publication title -

evolution medicine and public health

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 22

ISSN - 2050-6201

DOI - 10.1093/emph/eoy026

Subject(s) - pseudomonas aeruginosa , robustness (evolution) , biology , computational biology , computer science , bacteria , genetics , gene

We probed the evolutionary robustness of two antivirulence drugs, gallium and flucytosine, targeting the iron-scavenging pyoverdine in the opportunistic pathogen Pseudomonas aeruginosa . Using an experimental evolution approach in human serum, we showed that antivirulence treatments are not evolutionarily robust per se, but vary in their propensity to select for resistance.

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