Lost in translation | Zendy

Avantika Mainieri | Zendy; David Haig | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Lost in translation

Author(s) -

Avantika Mainieri,

David Haig

Publication year - 2018

Publication title -

evolution medicine and public health

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 22

ISSN - 2050-6201

DOI - 10.1093/emph/eoy008

Subject(s) - insulin like growth factor 1 receptor , biology , untranslated region , microrna , conserved sequence , translation (biology) , genetics , three prime untranslated region , computational biology , gene , messenger rna , receptor , peptide sequence , growth factor

The insulin-like growth factor (IGF) signaling system is a major arena of intragenomic conflict over embryonic growth between imprinted genes of maternal and paternal origin and the IGF type 1 receptor (IGF1R) promotes proliferation of many human cancers. The 3'-untranslated region (3'-UTR) of the mouse Igf1r mRNA is targeted by miR-675-3p derived from the imprinted H19 long noncoding RNA. We undertook a comparative sequence analysis of vertebrate IGF1R 3'-UTRs to determine the evolutionary history of miR-675 target sequences and to identify conserved features that are likely to be involved in post-transcriptional regulation of IGF1R translation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research