Early developmental exposures shape trade-offs between acquired and innate immunity in humans | Zendy

Alexander V. Georgiev | Zendy; Christopher W. Kuzawa | Zendy; Thomas W. McDade | Zendy

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Early developmental exposures shape trade-offs between acquired and innate immunity in humans

Author(s) -

Alexander V. Georgiev,

Christopher W. Kuzawa,

Thomas W. McDade

Publication year - 2016

Publication title -

evolution medicine and public health

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 22

ISSN - 2050-6201

DOI - 10.1093/emph/eow022

Subject(s) - innate immune system , biology , immunity , trade off , immunology , ecology , immune system

Life history theory predicts resource allocation trade-offs between competing functions and processes. We test the hypothesis that relative investment towards innate versus acquired immunity in humans is subject to such trade-offs and that three types of early developmental exposures are particularly salient in shaping adult immunophenotype: (i) pathogen exposure, (ii) nutritional resources; and (iii) extrinsic mortality cues.

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