Association between clinical antibiotic resistance and susceptibility ofPseudomonasin the cystic fibrosis lung | Zendy

Gunther Jansen | Zendy; Niels Mahrt | Zendy; Leif Tüeffers | Zendy; Camilo Barbosa | Zendy; Malte Harjes | Zendy; Gernot Adolph | Zendy; Anette Friedrichs | Zendy; Annegret Krenz-Weinreich | Zendy; Philip Rosenstiel | Zendy; Hinrich Schulenburg | Zendy

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Association between clinical antibiotic resistance and susceptibility ofPseudomonasin the cystic fibrosis lung

Author(s) -

Gunther Jansen,

Niels Mahrt,

Leif Tüeffers,

Camilo Barbosa,

Malte Harjes,

Gernot Adolph,

Anette Friedrichs,

Annegret Krenz-Weinreich,

Philip Rosenstiel,

Hinrich Schulenburg

Publication year - 2016

Publication title -

evolution medicine and public health

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 22

ISSN - 2050-6201

DOI - 10.1093/emph/eow016

Subject(s) - cystic fibrosis , pseudomonas aeruginosa , lung , antibiotics , medicine , antibiotic resistance , pseudomonas , microbiology and biotechnology , bacteria , biology , genetics

Cystic fibrosis patients suffer from chronic lung infections that require long-term antibiotic therapy. Pseudomonas readily evolve resistance, rendering antibiotics ineffective. In vitro experiments suggest that resistant bacteria may be treated by exploiting their collateral sensitivity to other antibiotics. Here, we investigate correlations of sensitivity and resistance profiles of Pseudomonas aeruginosa that naturally adapted to antibiotics in the cystic fibrosis lung.

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