Inheritance of the 8.1 ancestral haplotype in recurrent pregnancy loss | Zendy

Astrid Marie Kolte | Zendy; Henriette Svarre Nielsen | Zendy; Rudi Steffensen | Zendy; Bernard J. Crespi | Zendy; Ole Bjarne Christiansen | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Inheritance of the 8.1 ancestral haplotype in recurrent pregnancy loss

Author(s) -

Astrid Marie Kolte,

Henriette Svarre Nielsen,

Rudi Steffensen,

Bernard J. Crespi,

Ole Bjarne Christiansen

Publication year - 2015

Publication title -

evolution medicine and public health

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 22

ISSN - 2050-6201

DOI - 10.1093/emph/eov031

Subject(s) - haplotype , inheritance (genetic algorithm) , pregnancy , genealogy , genetics , biology , history , gene , allele

The 8.1 ancestral haplotype (AH) (HLA-A1, C7, B8, C4AQ0, C4B1, DR3, DQ2) is a remarkably long and conserved haplotype in the human major histocompatibility complex. It has been associated with both beneficial and detrimental effects, consistent with antagonistic pleiotropy. It has also been proposed that the survival of long, conserved haplotypes may be due to gestational drive, i.e. selective miscarriage of fetuses who have not inherited the haplotype from a heterozygous mother. Recurrent pregnancy loss (RPL) is defined as three or more consecutive pregnancy losses. The objective was to test the gestational drive theory for the 8.1AH in women with RPL and their live born children.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research