Clinical management of resistance evolution in a bacterial infection | Zendy

Robert J. Woods | Zendy; Andrew F. Read | Zendy

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Clinical management of resistance evolution in a bacterial infection

Author(s) -

Robert J. Woods,

Andrew F. Read

Publication year - 2015

Publication title -

evolution medicine and public health

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 22

ISSN - 2050-6201

DOI - 10.1093/emph/eov025

Subject(s) - antibiotic resistance , intensive care medicine , resistance (ecology) , drug resistance , antibiotics , medicine , evolutionary medicine , biological evolution , biology , microbiology and biotechnology , genetics , pathology , ecology

We report the case of a patient with a chronic bacterial infection that could not be cured. Drug treatment became progressively less effective due to antibiotic resistance, and the patient died, in effect from overwhelming evolution. Even though the evolution of drug resistance was recognized as a major threat, and the fundamentals of drug resistance evolution are well understood, it was impossible to make evidence-based decisions about the evolutionary risks associated with the various treatment options. We present this case to illustrate the urgent need for translational research in the evolutionary medicine of antibiotic resistance.

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