Divergent and convergent evolution in metastases suggest treatment strategies based on specific metastatic sites | Zendy

Jessica J. Cunningham | Zendy; Joel S. Brown | Zendy; T. L. Vincent | Zendy; Robert A. Gatenby | Zendy

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Divergent and convergent evolution in metastases suggest treatment strategies based on specific metastatic sites

Author(s) -

Jessica J. Cunningham,

Joel S. Brown,

T. L. Vincent,

Robert A. Gatenby

Publication year - 2015

Publication title -

evolution medicine and public health

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 22

ISSN - 2050-6201

DOI - 10.1093/emph/eov006

Subject(s) - divergence (linguistics) , metastatic tumor , metastasis , systemic therapy , primary tumor , cancer , medicine , molecular evolution , targeted therapy , oncology , evolutionary biology , biology , gene , phylogenetics , genetics , philosophy , linguistics , breast cancer

Systemic therapy for metastatic cancer is currently determined exclusively by the site of tumor origin. Yet, there is increasing evidence that the molecular characteristics of metastases significantly differ from the primary tumor. We define the evolutionary dynamics of metastases that govern this molecular divergence and examine their potential contribution to variations in response to targeted therapies.

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