Gallium-mediated siderophore quenching as an evolutionarily robust antibacterial treatment | Zendy

Adin RossGillespie | Zendy; Michael Weigert | Zendy; Sam P. Brown | Zendy; Rolf Kümmerli | Zendy

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Gallium-mediated siderophore quenching as an evolutionarily robust antibacterial treatment

Author(s) -

Adin RossGillespie,

Michael Weigert,

Sam P. Brown,

Rolf Kümmerli

Publication year - 2014

Publication title -

evolution medicine and public health

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 22

ISSN - 2050-6201

DOI - 10.1093/emph/eou003

Subject(s) - siderophore , virulence , gallium , microbiology and biotechnology , biology , extracellular , quenching (fluorescence) , galleria mellonella , bacteria , mutant , in vivo , chemistry , genetics , gene , physics , organic chemistry , quantum mechanics , fluorescence

Conventional antibiotics select strongly for resistance and are consequently losing efficacy worldwide. Extracellular quenching of shared virulence factors could represent a more promising strategy because (i) it reduces the available routes to resistance (as extracellular action precludes any mutations blocking a drug's entry into cells or hastening its exit) and (ii) it weakens selection for resistance, as fitness benefits to emergent mutants are diluted across all cells in a cooperative collective. Here, we tested this hypothesis empirically.

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