Hygiene and the world distribution of Alzheimer’s disease | Zendy

Molly Fox | Zendy; Leslie A. Knapp | Zendy; Paul W. Andrews | Zendy; Corey L. Fincher | Zendy

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Hygiene and the world distribution of Alzheimer’s disease

Author(s) -

Molly Fox,

Leslie A. Knapp,

Paul W. Andrews,

Corey L. Fincher

Publication year - 2013

Publication title -

evolution medicine and public health

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 22

ISSN - 2050-6201

DOI - 10.1093/emph/eot015

Subject(s) - hygiene , disease , hygiene hypothesis , sanitation , environmental health , epidemiology , demography , etiology , biology , gerontology , immunology , medicine , pathology , sociology

Alzheimer's disease (AD) shares certain etiological features with autoimmunity. Prevalence of autoimmunity varies between populations in accordance with variation in environmental microbial diversity. Exposure to microorganisms may improve individuals' immunoregulation in ways that protect against autoimmunity, and we suggest that this may also be the case for AD. Here, we investigate whether differences in microbial diversity can explain patterns of age-adjusted AD rates between countries.

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