Epistasis between antibiotic resistance mutations drives the evolution of extensively drug-resistant tuberculosis | Zendy

Sònia Borrell | Zendy; Youjin Teo | Zendy; Federica Giardina | Zendy; Elizabeth M. Streicher | Zendy; Marisa Klopper | Zendy; Julia Feldmann | Zendy; Borna Müller | Zendy; Tommie C. Victor | Zendy; Sébastien Gagneux | Zendy

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Epistasis between antibiotic resistance mutations drives the evolution of extensively drug-resistant tuberculosis

Author(s) -

Sònia Borrell,

Youjin Teo,

Federica Giardina,

Elizabeth M. Streicher,

Marisa Klopper,

Julia Feldmann,

Borna Müller,

Tommie C. Victor,

Sébastien Gagneux

Publication year - 2013

Publication title -

evolution medicine and public health

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 22

ISSN - 2050-6201

DOI - 10.1093/emph/eot003

Subject(s) - antibiotics , drug resistance , epistasis , tuberculosis , multiple drug resistance , antibiotic resistance , biology , drug , mycobacterium tuberculosis , genetics , medicine , pharmacology , gene , pathology

Multidrug resistant (MDR) bacteria are a growing threat to global health. Studies focusing on single antibiotics have shown that drug resistance is often associated with a fitness cost in the absence of drug. However, little is known about the fitness cost associated with resistance to multiple antibiotics.

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