Species interactions drive the spread of ampicillin resistance in human-associated gut microbiota | Zendy

Siobhán O’Brien | Zendy; Michael Baumgartner | Zendy; Alex R. Hall | Zendy

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Species interactions drive the spread of ampicillin resistance in human-associated gut microbiota

Author(s) -

Siobhán O’Brien,

Michael Baumgartner,

Alex R. Hall

Publication year - 2021

Publication title -

evolution medicine and public health

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 22

ISSN - 2050-6201

DOI - 10.1093/emph/eoab020

Subject(s) - ampicillin , antibiotic resistance , biology , antibiotics , microbiology and biotechnology , microcosm , gut flora , amp resistance , competition (biology) , antimicrobial , escherichia coli , colonisation resistance , ecology , immunology , genetics , gene

Slowing the spread of antimicrobial resistance is urgent if we are to continue treating infectious diseases successfully. There is increasing evidence microbial interactions between and within species are significant drivers of resistance. On one hand, cross-protection by resistant genotypes can shelter susceptible microbes from the adverse effects of antibiotics, reducing the advantage of resistance. On the other hand, antibiotic-mediated killing of susceptible genotypes can alleviate competition and allow resistant strains to thrive (competitive release). Here, by observing interactions both within and between species in microbial communities sampled from humans, we investigate the potential role for cross-protection and competitive release in driving the spread of ampicillin resistance in the ubiquitous gut commensal and opportunistic pathogen Escherichia coli .

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