Vector dynamics influence spatially imperfect genetic interventions against disease | Zendy

Mete K Yuksel | Zendy; Christopher H. Remien | Zendy; Bandita Karki | Zendy; James J. Bull | Zendy; Stephen M. Krone | Zendy

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Vector dynamics influence spatially imperfect genetic interventions against disease

Author(s) -

Mete K Yuksel,

Christopher H. Remien,

Bandita Karki,

James J. Bull,

Stephen M. Krone

Publication year - 2020

Publication title -

evolution medicine and public health

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 22

ISSN - 2050-6201

DOI - 10.1093/emph/eoaa035

Subject(s) - imperfect , disease , biology , psychological intervention , medicine , microbiology and biotechnology , philosophy , linguistics , psychiatry

Genetic engineering and similar technologies offer promising new approaches to controlling human diseases by blocking transmission from vectors. However, in spatially structured populations, imperfect coverage of the vector will leave pockets in which the parasite may persist. Movement by humans may disrupt this local persistence and facilitate eradication when these pockets are small, spreading parasite reproduction outside unprotected areas and into areas that block its reproduction. Here, we consider the sensitivity of this process to biological details: do simple generalities emerge that may facilitate interventions?

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