Effect of drug dose and timing of treatment on the emergence of drug resistance in vivo in a malaria model | Zendy

Mónica Mancero Acosta | Zendy; Joshua T. Bram | Zendy; Derek G. Sim | Zendy; Andrew F. Read | Zendy

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Effect of drug dose and timing of treatment on the emergence of drug resistance in vivo in a malaria model

Author(s) -

Mónica Mancero Acosta,

Joshua T. Bram,

Derek G. Sim,

Andrew F. Read

Publication year - 2020

Publication title -

evolution medicine and public health

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 22

ISSN - 2050-6201

DOI - 10.1093/emph/eoaa016

Subject(s) - atovaquone , plasmodium chabaudi , drug resistance , context (archaeology) , population , drug , biology , pharmacology , malaria , medicine , in vivo , immunology , parasitemia , plasmodium falciparum , microbiology and biotechnology , genetics , environmental health , paleontology

There is a significant interest in identifying clinically effective drug treatment regimens that minimize the de novo evolution of antimicrobial resistance in pathogen populations. However, in vivo studies that vary treatment regimens and directly measure drug resistance evolution are rare. Here, we experimentally investigate the role of drug dose and treatment timing on resistance evolution in an animal model.

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