Open AccessAre treatment effect assumptions in orthodontic studies overoptimistic?
Author(s) -
Jadbinder Seehra,
Daniel StonehouseSmith,
Martyn T. Cobourne,
Michail Tsagris,
Nikolaos Pandis
Publication year - 2021
Publication title -
european journal of orthodontics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.252
H-Index - 84
eISSN - 1460-2210
pISSN - 0141-5387
DOI - 10.1093/ejo/cjab018
Subject(s) - interquartile range , sample size determination , statistics , meta analysis , medicine , treatment effect , mathematics , range (aeronautics) , materials science , traditional medicine , composite material
At the clinical trial design stage, assumptions regarding the treatment effects to be detected should be appropriate so that the required sample size can be calculated. There is evidence in the medical literature that sample size assumption can be overoptimistic. The aim of this study was to compare the distribution of the assumed effects versus that of the observed effects as a proxy for overoptimistic treatment effect assumptions at the study design stage.
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