Bolus injection or continuous infusion for the assessment of myocardial blood flow during perfusion stress echocardiography?

We read the recent article by Wejner-Mik et al. 1 in the Journal with great interest and we congratulate them on their study which re-emphasizes both the clinical value of myocardial contrast echocardiography (MCE) and specifically the prognostic value of dipyridamole MCE. Both real-time and triggered imaging techniques were used, highlighting the robust nature of each method. We wish to highlight certain methodological aspects which may be of use in planning future studies.First, the contrast agent (Optison) was administered by repeated bolus injections rather than a continuous intravenous infusion. The pioneering …