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Echo contrast agents are widely used and safe but can rarely produce serious side effects. This-to the author's knowledge-is the first detailed published case report of a patient who had a severe and complex sequence of adverse reactions within 3 min of having an intravenous infusion of Sonovue initiated, and where the causal connection between Sonovue and the adverse reaction is not diluted by potential side effects from dobutamine.

european heart journal. cardiovascular imaging

Bubble trouble: anaphylactic shock, threatened myocardial infarction, and transient renal failure after intravenous echo contrast for left ventricular cavity opacification preceding dobutamine stress echo