Cardiac and neurological implications in beta-thalassemia with left ventricular hypertrabeculation/non-compaction

We read with interest the report of Luckie et al. about male twins with thalassemia and cardiac iron overload in whom left ventricular hypertrabeculation/non-compaction (LVHT) was detected echocardiographically.1 Surprisingly, their 1-year younger sister, who also suffered from thalassemia, did not show LVHT. The report raises the following questions:Are previous echocardiograms of the three siblings available in order to assess whether LVHT was congenital, acquired, or disappeared during lifetime.2,3The three siblings underwent cardiac magnetic resonance imaging (cMRI) to look for cardiac iron overload. It would be of interest if cMRI, which is reported to be superior to echocardiography, …