Duration of right ventricular contraction predicts the efficacy of bosentan treatment in patients with pulmonary hypertension | Zendy

M. G. J. Duffels | Zendy; Maxim Hardziyenka | Zendy; Sulaiman Surie | Zendy; Rianne H.A.C.M. de BruinBon | Zendy; Elke S. Hoendermis | Zendy; Arie P.J. van Dijk | Zendy; Berto J. Bouma | Zendy; Han L. Tan | Zendy; Rolf M.F. Berger | Zendy; Paul Bresser | Zendy; Barbara J.M. Mulder | Zendy

Open Access

Duration of right ventricular contraction predicts the efficacy of bosentan treatment in patients with pulmonary hypertension

Author(s) -

M. G. J. Duffels,

Maxim Hardziyenka,

Sulaiman Surie,

Rianne H.A.C.M. de BruinBon,

Elke S. Hoendermis,

Arie P.J. van Dijk,

Berto J. Bouma,

Han L. Tan,

Rolf M.F. Berger,

Paul Bresser,

Barbara J.M. Mulder

Publication year - 2008

Publication title -

european journal of echocardiography

Language(s) - English

Resource type - Journals

eISSN - 1525-2167

pISSN - 1532-2114

DOI - 10.1093/ejechocard/jen308

Subject(s) - bosentan , medicine , cardiology , contraction (grammar) , pulmonary hypertension , endothelin 1 , endothelin receptor , receptor

In patients with pulmonary hypertension (PH), elevated endothelin-1 levels are associated with prolonged duration of right ventricular (RV) contraction, which induces leftward ventricular septal bowing with impaired left diastolic filling. We hypothesized that baseline RV contraction duration predicts efficacy of endothelin receptor antagonist, bosentan.

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