Defective NOTCH signalling drives smooth muscle cell death and differentiation in bicuspid aortic valve aortopathy | Zendy

Oliver J. Harrison | Zendy; Christopher Torrens | Zendy; Kareem Salhiyyah | Zendy; Amit Modi | Zendy; Narain Moorjani | Zendy; Paul A. Townsend | Zendy; Sunil K. Ohri | Zendy; Felino R. Cagampang | Zendy

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Defective NOTCH signalling drives smooth muscle cell death and differentiation in bicuspid aortic valve aortopathy

Author(s) -

Oliver J. Harrison,

Christopher Torrens,

Kareem Salhiyyah,

Amit Modi,

Narain Moorjani,

Paul A. Townsend,

Sunil K. Ohri,

Felino R. Cagampang

Publication year - 2018

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1093/ejcts/ezy464

Subject(s) - bicuspid aortic valve , apoptosis , vascular smooth muscle , ascending aorta , notch signaling pathway , aortic valve , biology , medicine , microbiology and biotechnology , anatomy , aorta , signal transduction , genetics , smooth muscle

Bicuspid aortic valve disease is common and is associated with ascending aortic aneurysms. Vascular smooth muscle cell (VSMC) apoptosis is characteristic of the ascending aorta of bicuspid patients, and NOTCH1 gene mutations have also been linked to the disease. NOTCH signalling is a fundamental cell signalling pathway, which dictates cell fate decisions including apoptosis. Our objective was to elucidate the role of NOTCH signalling in VSMC apoptosis and differentiation in bicuspid aortopathy.

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