Extracorporeal immunoadsorption in heparin- and protamine-induced thrombocytopaenia prior to cardiac surgery | Zendy

Lisa Füreder | Zendy; Georg A. Böhmig | Zendy; AnneKristin Schaefer | Zendy; Barbara Steinlechner | Zendy

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Extracorporeal immunoadsorption in heparin- and protamine-induced thrombocytopaenia prior to cardiac surgery

Author(s) -

Lisa Füreder,

Georg A. Böhmig,

AnneKristin Schaefer,

Barbara Steinlechner

Publication year - 2018

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1093/ejcts/ezy411

Subject(s) - protamine , heparin , cardiopulmonary bypass , medicine , immunoadsorption , extracorporeal , cardiac surgery , extracorporeal circulation , anticoagulant , anesthesia , surgery , cardiology , antibody , immunology

Exposure to heparin and protamine during cardiac surgery on cardiopulmonary bypass (CPB) may trigger heparin-induced thrombocytopaenia and/or protamine-induced thrombocytopaenia. Further surgery on CPB with heparin and protamine in the presence of these antibodies implies increased thromboembolic risk. We present the successful application of extracorporeal immunoadsorption to deplete antibodies causing heparin-induced and protamine-induced thrombocytopaenia preoperatively.

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