Prognostic value of Twist, Snail and E-cadherin expression in pathological N0 non-small-cell lung cancer: a retrospective cohort study | Zendy

Guanghui Wang | Zendy; Wei Ma | Zendy; Yun Li | Zendy; Yuanzhu Jiang | Zendy; Guoyuan Ma | Zendy; Xiangwei Zhang | Zendy; Long Meng | Zendy; Jiajun Du | Zendy

Open Access

Prognostic value of Twist, Snail and E-cadherin expression in pathological N0 non-small-cell lung cancer: a retrospective cohort study

Author(s) -

Guanghui Wang,

Wei Ma,

Yun Li,

Yuanzhu Jiang,

Guoyuan Ma,

Xiangwei Zhang,

Long Meng,

Jiajun Du

Publication year - 2018

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1093/ejcts/ezy022

Subject(s) - snail , pathological , retrospective cohort study , cadherin , twist , oncology , medicine , cohort , lung cancer , cancer , value (mathematics) , cell , pathology , biology , statistics , genetics , mathematics , ecology , geometry

Lung cancer is the leading cause of cancer-related death worldwide. The 5-year survival rate for patients after curative surgery with pathological N0 non-small-cell lung cancer (NSCLC) is as low as 56%, which is due to recurrence and metastasis. Emerging evidence suggests that epithelial-mesenchymal transition is important for cancer metastasis. Twist and Snail are epithelial-mesenchymal transition regulators that induce metastasis by down-regulating E-cadherin. The aim of this study was to evaluate the prognostic value of Twist, Snail and E-cadherin expression in patients with resectable pathological N0 NSCLC.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research