Open AccessImpact of T-cell-mediated immune response on xenogeneic heart valve transplantation: short-term success and mid-term failure
Author(s) -
Anna Biermann,
Julia Marzi,
Eva Brauchle,
Maria Schneider,
Angela Kornberger,
Sherif Abdelaziz,
Julian L. Wichmann,
Christophe Arendt,
Eike Nagel,
Kelvin Brockbank,
Martina Seifert,
Katja SchenkeLayland,
Ulrich A. Stock
Publication year - 2017
Publication title -
european journal of cardio-thoracic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.303
H-Index - 133
eISSN - 1873-734X
pISSN - 1010-7940
DOI - 10.1093/ejcts/ezx396
Subject(s) - transplantation , immunogenicity , extracellular matrix , immune system , cryopreservation , medicine , andrology , pathology , immunology , elastin , heart valve , biology , microbiology and biotechnology , surgery , embryo
Allogeneic frozen cryopreserved heart valves (allografts or homografts) are commonly used in clinical practice. A major obstacle for their application is the limited availability in particular for paediatrics. Allogeneic large animal studies revealed that alternative ice-free cryopreservation (IFC) results in better matrix preservation and reduced immunogenicity. The objective of this study was to evaluate xenogeneic (porcine) compared with allogeneic (ovine) IFC heart valves in a large animal study.
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