Open AccessThe angiotensin II type 1 receptor blocker losartan attenuates bioprosthetic valve leaflet calcification in a rabbit intravascular implant model
Author(s) -
Hong Ju Shin,
DaeHyun Kim,
Han Ki Park,
Young Hwan Park
Publication year - 2016
Publication title -
european journal of cardio-thoracic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.303
H-Index - 133
eISSN - 1873-734X
pISSN - 1010-7940
DOI - 10.1093/ejcts/ezw191
Subject(s) - losartan , medicine , calcification , osteopontin , western blot , angiotensin ii , implant , endocrinology , urology , saline , angiotensin receptor , new zealand white rabbit , receptor , surgery , chemistry , biology , paleontology , biochemistry , gene
There is evidence that angiotensin II type I receptor blocker (ARB) could reduce structural valve deterioration. However, the anticalcification effect on the bioprosthetic heart valve (BHV) has not been investigated. Thus, we investigated the effects of losartan (an ARB) on calcification of implanted bovine pericardial tissue in a rabbit intravascular implant model.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom