Donor pretreatment with adenosine monophosphate-activated protein kinase activator protects cardiac grafts from cold ischaemia/reperfusion injury | Zendy

Chao Yang | Zendy; Honglai Xu | Zendy; Lan-jun Cai | Zendy; Xiaoxiao Du | Zendy; Yinan Jiang | Zendy; Yong Zhang | Zendy; Hongmin Zhou | Zendy; Zhonghua Klaus Chen | Zendy

Open Access

Donor pretreatment with adenosine monophosphate-activated protein kinase activator protects cardiac grafts from cold ischaemia/reperfusion injury

Author(s) -

Chao Yang,

Honglai Xu,

Lan-jun Cai,

Xiaoxiao Du,

Yinan Jiang,

Yong Zhang,

Hongmin Zhou,

Zhonghua Klaus Chen

Publication year - 2015

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1093/ejcts/ezv413

Subject(s) - creatine kinase , ampk , reperfusion injury , adenosine monophosphate , viaspan , chemistry , adenine nucleotide , activator (genetics) , medicine , protein kinase a , lactate dehydrogenase , adenosine , pharmacology , endocrinology , ischemia , andrology , biochemistry , kinase , enzyme , nucleotide , gene , receptor

Adenosine monophosphate-activated protein kinase (AMPK) is a master regulator of energy metabolism and has been shown to be protective in ischaemia/reperfusion injury (IRI). We hypothesized that preactivation of AMPK with an activator before donor heart procurement could protect heart grafts from cold IRI.

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