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Cardiac transplantation using hearts from donors after circulatory death (DCD) is critically limited by the unavoidable warm ischaemia and its related unpredictable graft function. Inasmuch as hypothermic machine perfusion (MP) has been shown to improve heart preservation, we hypothesized that MP could enable the use of DCD hearts for transplantation.

european journal of cardio-thoracic surgery

Hypothermic continuous machine perfusion enables preservation of energy charge and functional recovery of heart grafts in an<i>ex vivo</i>model of donation following circulatory death

Hypothermic continuous machine perfusion enables preservation of energy charge and functional recovery of heart grafts in anex vivomodel of donation following circulatory death