Hypothermic continuous machine perfusion enables preservation of energy charge and functional recovery of heart grafts in anex vivomodel of donation following circulatory death | Zendy

Olivier Van Caenegem | Zendy; Christophe Beauloye | Zendy; Luc Bertrand | Zendy; Sandrine Horman | Zendy; Sophie Lepropre | Zendy; Grégory Sparavier | Zendy; Jonathan Vercruysse | Zendy; Noëlla Bethuyne | Zendy; Alain Poncelet | Zendy; Pierre Gianello | Zendy; Peter Demuylder | Zendy; E. Legrand | Zendy; Gwen Beaurin | Zendy; Françoise Bontemps | Zendy; Luc Jacquet | Zendy; JeanLouis Vanoverschelde | Zendy

Open Access

Hypothermic continuous machine perfusion enables preservation of energy charge and functional recovery of heart grafts in anex vivomodel of donation following circulatory death

Author(s) -

Olivier Van Caenegem,

Christophe Beauloye,

Luc Bertrand,

Sandrine Horman,

Sophie Lepropre,

Grégory Sparavier,

Jonathan Vercruysse,

Noëlla Bethuyne,

Alain Poncelet,

Pierre Gianello,

Peter Demuylder,

E. Legrand,

Gwen Beaurin,

Françoise Bontemps,

Luc Jacquet,

JeanLouis Vanoverschelde

Publication year - 2015

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1093/ejcts/ezv409

Subject(s) - phosphocreatine , ex vivo , contractility , machine perfusion , creatine , energy charge , heart transplantation , transplantation , perfusion , cardiology , viaspan , medicine , in vivo , circulatory system , cold storage , ischemia , adenine nucleotide , chemistry , energy metabolism , biology , biochemistry , receptor , microbiology and biotechnology , horticulture , adenylate kinase , liver transplantation , nucleotide , gene

Cardiac transplantation using hearts from donors after circulatory death (DCD) is critically limited by the unavoidable warm ischaemia and its related unpredictable graft function. Inasmuch as hypothermic machine perfusion (MP) has been shown to improve heart preservation, we hypothesized that MP could enable the use of DCD hearts for transplantation.

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