Impact of levosimendan and ischaemia–reperfusion injury on myocardial subsarcolemmal mitochondrial respiratory chain, mitochondrial membrane potential, Ca2+cycling and ATP synthesis | Zendy

Stefanie Sommer | Zendy; M. Leistner | Zendy; Ivan Aleksić | Zendy; Christoph Schimmer | Zendy; K. Alhussini | Zendy; Peer Kanofsky | Zendy; Rainer Leyh | Zendy; Sebastian-Patrick Sommer | Zendy

Open Access

Impact of levosimendan and ischaemia–reperfusion injury on myocardial subsarcolemmal mitochondrial respiratory chain, mitochondrial membrane potential, Ca²⁺cycling and ATP synthesis

Author(s) -

Stefanie Sommer,

M. Leistner,

Ivan Aleksić,

Christoph Schimmer,

K. Alhussini,

Peer Kanofsky,

Rainer Leyh,

Sebastian-Patrick Sommer

Publication year - 2015

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1093/ejcts/ezv397

Subject(s) - levosimendan , mitochondrial permeability transition pore , contractility , perfusion , cardiology , medicine , ventricular pressure , chemistry , ischemia , respiratory chain , mptp , mitochondrion , hemodynamics , heart failure , biochemistry , apoptosis , programmed cell death , dopaminergic , dopamine

Levosimendan (LS) is increasingly used in case of myocardial failure after cardiac surgery. The impact of LS on myocardial mitochondrial functions, such as respiratory chain function (RCF), mitochondrial membrane potential (ΔΨm), Ca(2+) handling, mitochondrial permeability transition pore (mPTP) opening and ATP during ongoing ischaemia/reperfusion (IR) injury, is not well understood. Depending on LS, I/R injury or the combination of both, we analysed myocardial functions in a retrograde Langendorff-model followed by the analysis of subsarcolemmal mitochondrial (SSM) functions.

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