Open AccessPerivenous application of cyanoacrylate tissue sealants reduces intimal and medial thickening of the vein graft and inflammatory responses in a rabbit model of carotid artery bypass grafting
Author(s) -
Longsheng Dai,
Mingxin Gao,
Chengxiong Gu,
Fan Zhang,
Yang Yu
Publication year - 2015
Publication title -
european journal of cardio-thoracic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.303
H-Index - 133
eISSN - 1873-734X
pISSN - 1010-7940
DOI - 10.1093/ejcts/ezv111
Subject(s) - medicine , intimal hyperplasia , artery , jugular vein , surgery , anastomosis , common carotid artery , internal elastic lamina , neointimal hyperplasia , cyanoacrylate , blood vessel , proinflammatory cytokine , inflammation , carotid arteries , chemistry , adhesive , smooth muscle , stent , restenosis , organic chemistry , layer (electronics)
Effective therapies to prevent vein graft failure after coronary artery bypass grafting (CABG) are still lacking. α-Cyanoacrylate (α-CA, 99% n-octyl-α-cyanoacrylate + n-butyl-α-cyanoacrylate) has been increasingly used as a tissue sealant for wound closure because of its bacteriostatic, biodegradable and haemostatic properties. As a strong tissue adhesive, α-CA might prevent an arterial circulation-induced mechanical stretch on vein graft to attenuate intimal hyperplasia. Here, we investigated the effects of perivenous application of α-CA on the vein graft in a rabbit model of carotid artery bypass grafting.
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