Open AccessThe depletion of donor macrophages reduces ischaemia-reperfusion injury after mouse lung transplantation
Author(s) -
Yukio Tsushima,
Jehee Jang,
Yoshito Yamada,
Reto A. Schwendener,
Kaori Suzuki,
Walter Weder,
Wolfgang Jungraithmayr
Publication year - 2013
Publication title -
european journal of cardio-thoracic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.303
H-Index - 133
eISSN - 1873-734X
pISSN - 1010-7940
DOI - 10.1093/ejcts/ezt489
Subject(s) - reperfusion injury , lactate dehydrogenase , lung , transplantation , andrology , histology , apoptosis , medicine , necrosis , tumor necrosis factor alpha , hmgb1 , lung transplantation , immune system , pathology , chemistry , ischemia , immunology , inflammation , biochemistry , enzyme
Macrophages (M) are one of the most important cells of the innate immune system for first line defense. Upon transplantation (Tx), M play a prominent role during lung ischaemia reperfusion (I/R) injury. Here, we hypothesize that the depletion of donor M ameliorates the post-transplant lung I/R injury.
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