Open AccessA novel glutamate transporter blocker, LL-TBOA, attenuates ischaemic injury in the isolated, perfused rat heart despite low transporter levels
Author(s) -
Vladimir Martinov,
Yvette Dehnes,
Silvia Holmseth,
Keiko Shimamoto,
Niels C. Danbolt,
Guro Valen
Publication year - 2013
Publication title -
european journal of cardio-thoracic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.303
H-Index - 133
eISSN - 1873-734X
pISSN - 1010-7940
DOI - 10.1093/ejcts/ezt487
Subject(s) - transporter , excitatory amino acid transporter , pharmacology , chemistry , glutamate receptor , medicine , biochemistry , receptor , gene
Loss of glutamate from cardiomyocytes during ischaemia may aggravate ischaemia-reperfusion injury in open heart surgery. This may be due to reversal of excitatory amino acid transporters (EAATs). However, the expression of such transporters in cardiomyocytes is ambiguous and quantitative data are lacking. Our objective was to study whether EAATs were expressed in the rat heart and to study whether blocking of transporter operation during cardiac ischaemia could be beneficial.
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