Assessment of aortic valve pressure overload and leaflet functions in an ex vivo beating heart loaded with a continuous flow cardiac assist device | Zendy

E. Tüzün | Zendy; Kim A.M.A. Pennings | Zendy; Sjoerd van Tuijl | Zendy; J. de Hart | Zendy; Marco Stijnen | Zendy; Frans N. van de Vosse | Zendy; Bas A.J.M. de Mol | Zendy; M.C.M. Rutten | Zendy

Open Access

Assessment of aortic valve pressure overload and leaflet functions in an ex vivo beating heart loaded with a continuous flow cardiac assist device

Author(s) -

E. Tüzün,

Kim A.M.A. Pennings,

Sjoerd van Tuijl,

J. de Hart,

Marco Stijnen,

Frans N. van de Vosse,

Bas A.J.M. de Mol,

M.C.M. Rutten

Publication year - 2013

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1093/ejcts/ezt355

Subject(s) - cardiology , medicine , pulsatile flow , aortic valve , aortic pressure , regurgitation (circulation) , hemodynamics , ventricular pressure , ex vivo , diastole , ventricular assist device , pulse pressure , preload , ventricle , heart failure , blood pressure , in vivo , microbiology and biotechnology , biology

Aortic valve regurgitation, fusion and thrombosis are commonly reported clinical complications after continuous flow ventricular assist device implantations; however, the complex interaction between reduced pulsatile flow physiology and aortic valve functions has not been studied experimentally. To address this, a continuous flow left ventricular assist device was implanted in four swine ex vivo beating hearts and then operated at baseline (device off, no flow) and at device speeds ranging between 8500 and 11,500 rpm under healthy and experimentally created failing heart conditions.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research