Open AccessIschaemic preconditioning prevents the liver inflammatory response to lung ischaemia/reperfusion in a swine lung autotransplant model†
Author(s) -
Luis Huerta,
Lisa Rancán,
Carlos Simón,
Jesús Isea,
Eduardo Vidaurre,
Elena Vara,
Ignacio Garutti,
Federico GonzálezAragoneses
Publication year - 2012
Publication title -
european journal of cardio-thoracic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.303
H-Index - 133
eISSN - 1873-734X
pISSN - 1010-7940
DOI - 10.1093/ejcts/ezs599
Subject(s) - lung , medicine , pneumonectomy , ischemia , reperfusion injury , tumor necrosis factor alpha , proinflammatory cytokine , ischemic preconditioning , pathology , inflammation
Lung ischaemia/reperfusion (IR) induces a systemic inflammatory response that causes damage to remote organs. The liver is particularly sensitive to circulating inflammatory mediators that occur after IR of remote organs. Recently, remote ischaemic preconditioning has been proposed as a surgical tool to protect several organs from IR. The present study was designed to investigate a possible protective effect of lung ischaemic preconditioning (IP) against the liver inflammatory response to lung IR.
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