Acetylsalicylic acid treatment until surgery reduces oxidative stress and inflammation in patients undergoing coronary artery bypass grafting | Zendy

Kirsti Berg | Zendy; Mette Langaas | Zendy; Madelene Ericsson | Zendy; Hilde Pleym | Zendy; Samar Basu | Zendy; Ivar S. Nordrum | Zendy; Nicola Vitale | Zendy; Rune Haaverstad | Zendy

Open Access

Acetylsalicylic acid treatment until surgery reduces oxidative stress and inflammation in patients undergoing coronary artery bypass grafting

Author(s) -

Kirsti Berg,

Mette Langaas,

Madelene Ericsson,

Hilde Pleym,

Samar Basu,

Ivar S. Nordrum,

Nicola Vitale,

Rune Haaverstad

Publication year - 2012

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1093/ejcts/ezs591

Subject(s) - bypass grafting , medicine , artery , oxidative stress , inflammation , grafting , cardiology , surgery , coronary artery bypass surgery , materials science , composite material , polymer

Acetylsalicylic acid (ASA) is a cornerstone in the treatment of coronary artery disease (CAD) due to its antiplatelet effect. Cessation of aspirin before coronary artery bypass grafting (CABG) is often recommended to avoid bleeding, but the practice is controversial because it is suggested to worsen the underlying CAD. The aims of the present prospective, randomized study were to assess if ASA administration until the day before CABG decreases the oxidative load through a reduction of inflammation and myocardial damage, compared with patients with preoperative discontinuation of ASA.

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