Simvastatin attenuates pulmonary vascular remodelling by down-regulating matrix metalloproteinase-1 and -9 expression in a carotid artery-jugular vein shunt pulmonary hypertension model in rats | Zendy

Yao Jiang | Zendy; Maoming Xiong | Zendy; Baozhen Tang | Zendy; Guowei Chen | Zendy; Liang Ming | Zendy; Xiaojing Ma | Zendy; Zhi Wang | Zendy; Zexuan Wu | Zendy

Open Access

Simvastatin attenuates pulmonary vascular remodelling by down-regulating matrix metalloproteinase-1 and -9 expression in a carotid artery-jugular vein shunt pulmonary hypertension model in rats

Author(s) -

Yao Jiang,

Maoming Xiong,

Baozhen Tang,

Guowei Chen,

Liang Ming,

Xiaojing Ma,

Zhi Wang,

Zexuan Wu

Publication year - 2012

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1093/ejcts/ezs445

Subject(s) - simvastatin , medicine , pulmonary artery , pulmonary hypertension , cardiology , hemodynamics

It remains controversial as to whether simvastatin has a beneficial effect on pulmonary artery hypertension. This study aimed to explore the efficacy of simvastatin on haemodynamic changes, pulmonary vascular remodelling and expression of matrix metalloproteinase-1 and -9 (MMP-1,9) in a carotid artery-jugular vein (CA-JV) shunt pulmonary artery hypertension (PAH) model in rats.

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