Open AccessInhibition of cell surface expression of endothelial adhesion molecules by ursolic acid prevents intimal hyperplasia of venous bypass grafts in rats
Author(s) -
Iris Zeller,
Dominik Wiedemann,
Stefan Schwaiger,
Marlies Stelzmüller,
Simone Barbara Kreutmayer,
O. Leberfing,
H Stuppner,
David Bernhard
Publication year - 2012
Publication title -
european journal of cardio-thoracic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.303
H-Index - 133
eISSN - 1873-734X
pISSN - 1010-7940
DOI - 10.1093/ejcts/ezs128
Subject(s) - intimal hyperplasia , hyperplasia , endothelial stem cell , ursolic acid , in vivo , apoptosis , vcam 1 , cell , cell adhesion molecule , medicine , pathology , immunology , chemistry , biology , in vitro , icam 1 , smooth muscle , biochemistry , microbiology and biotechnology , chromatography
Despite rapid progress in surgical techniques, there is still a significant lack of surgery-supportive pharmacological treatments. The aim of this study was to test the hypothesis that ursolic acid (UA) may prevent intimal hyperplasia of venous bypass grafts.
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