Isolated lung perfusion with gemcitabine combined with radiotherapy: no additional lung toxicity in an experimental model | Zendy

J. Van Thielen | Zendy; Anouk Wittock | Zendy; Jeroen Hendriks | Zendy; Willem den Hengst | Zendy; Christel De Pooter | Zendy; D. Van den Weyngaert | Zendy; Patrick Pauwels | Zendy; Paul Van Schil | Zendy

Open Access

Isolated lung perfusion with gemcitabine combined with radiotherapy: no additional lung toxicity in an experimental model

Author(s) -

J. Van Thielen,

Anouk Wittock,

Jeroen Hendriks,

Willem den Hengst,

Christel De Pooter,

D. Van den Weyngaert,

Patrick Pauwels,

Paul Van Schil

Publication year - 2012

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1093/ejcts/ezs024

Subject(s) - gemcitabine , medicine , perfusion , lung , toxicity , chemotherapy , gastroenterology , urology , pathology

Isolated lung perfusion with gemcitabine is an effective technique for the treatment of lung metastases in an experimental model. In clinical studies, increased toxicity has been observed when combining intravenous gemcitabine with radiotherapy (RT). The goal of our study was to determine whether RT in combination with isolated lung perfusion increases lung toxicity.

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